Source:http://linkedlifedata.com/resource/pubmed/id/16861622
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2006-9-29
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pubmed:abstractText |
The relevance of apolipoprotein A-V (apoA-V) for human lipid homeostasis is underscored by genetic association studies and the identification of truncation-causing mutations in the APOA5 gene as a cause of type V hyperlipidemia, compatible with an LPL-activating role of apoA-V. An inverse correlation between plasma apoA-V and triglyceride (TG) levels has been surmised from animal data. Recent studies in human subjects using (semi)quantitative immunoassays, however, do not provide unambiguous support for such a relationship. Here, we used a novel, validated ELISA to measure plasma apoA-V levels in patients (n = 28) with hypertriglyceridemia (HTG; 1.8-78.7 mmol TG/l) and normolipidemic controls (n = 42). Unexpectedly, plasma apoA-V levels were markedly increased in the HTG subjects compared with controls (1,987 vs. 258 ng/ml; P < 0.001). In the HTG group, apoA-V and TG were positively correlated (r = +0.44, P = 0.02). In addition, we noted an increased level of the LPL-inhibitory protein apoC-III in the HTG group (45.8 vs. 10.6 mg/dl in controls; P < 0.001). The correlation between apoA-V and TG levels in the HTG group disappeared (partial r = +0.09, P = 0.65) when controlling for apoC-III levels. In contrast, apoC-III and TG remained positively correlated in this group when controlling for apoA-V (partial r = +0.43, P = 0.025). Our findings suggest that in HTG patients, increased TG levels are accompanied by high plasma levels of apoA-V and apoC-III, apolipoproteins with opposite modes of action. This study provides evidence for a complex interaction between apoA-V and apoC-III in patients with severe HTG.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2275
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pubmed:author |
pubmed-author:BerbéeJimmy F PJF,
pubmed-author:ChamuleauRobert A F MRA,
pubmed-author:GroenAlbert KAK,
pubmed-author:HattoriHiroakiH,
pubmed-author:KuivenhovenJan AlbertJA,
pubmed-author:NiermanMelchior CMC,
pubmed-author:RensenPatrick C NPC,
pubmed-author:SchaapFrank GFG,
pubmed-author:TalmudPhilippa JPJ,
pubmed-author:VaessenStefan F CSF
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2333-9
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pubmed:meshHeading |
pubmed-meshheading:16861622-Apolipoprotein C-III,
pubmed-meshheading:16861622-Apolipoproteins A,
pubmed-meshheading:16861622-Calibration,
pubmed-meshheading:16861622-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16861622-Humans,
pubmed-meshheading:16861622-Hypertriglyceridemia,
pubmed-meshheading:16861622-Triglycerides
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pubmed:year |
2006
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pubmed:articleTitle |
Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia.
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pubmed:affiliation |
Academic Medical Center Liver Center, 1105 BK Amsterdam, The Netherlands. f.g.schaap@amc.uva.nl
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pubmed:publicationType |
Journal Article
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