Linked Life Data

16860268

Source:http://linkedlifedata.com/resource/pubmed/id/16860268

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-7-24
pubmed:abstractText
Historically, women have lived longer than men in almost every country in the world. A similar pattern of sex differences in longevity is also found in many other species; however, it is not clear if there are more species in which females live longer or vice versa. For virtually all the primary causes of death and at virtually all ages, mortality rates are higher for men. Women do not live longer than men because they age more slowly, but because they are more robust at every age. Paradoxically, although women have lower mortality rates they have higher overall rates of physical illness than do men. Several hypotheses have been proposed for sex differences in longevity, including more active female immune functioning, the protective effect of estrogen, compensatory effects of the second X chromosome, reduction in the activity of growth hormone and the insulin-like growth factor 1 signaling cascade, and the influence of oxidative stress on aging and disease. At present, none of these hypotheses are strongly supported, although weak support is available for the oxidative stress hypothesis. With the advent of more rapid genome sequencing, molecular tools will become available for more species, thus further detailing the causes for the differences in longevity between the sexes.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1550-8579
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-92
pubmed:dateRevised
2011-1-24
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Why women live longer than men: sex differences in longevity.
pubmed:affiliation
Deparment of Cellular and Structural Biology, Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA. austad@uthscsa.edu
pubmed:publicationType
Journal Article, Comparative Study