Source:http://linkedlifedata.com/resource/pubmed/id/16860013
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2006-7-24
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pubmed:abstractText |
Clinical use of cardiac computed tomography is rapidly expanding, and its purpose may reach beyond noninvasive coronary angiography. We investigated the ability of 64-slice multidetector computed tomography to differentiate between recent and long-standing myocardial infarction (MI). Contrast-enhanced coronary computed tomographic (CT) scans (Siemens Sensation 64) of patients with a recent MI (< 7 days, n = 16), long-standing MI (> 12 months, n = 13), and no MI (n = 13) were retrospectively evaluated. To anticipate transmural variation of myocardial perfusion and to neutralize image noise, a series of thin, overlapping slices was created in parallel alignment to the myocardial wall. Within each of these slices, a small region of interest was placed at a constant in-plane position to measure the CT attenuation (Hounsfield units [HU]) at consecutive transmural locations of injured and normal remote myocardium. In addition, wall thickness and the myocardial cavity were measured. Significantly lower CT attenuation values were found in patients with long-standing MI (-13 +/- 37 HU) than in those with acute MI (26 +/- 26 HU) and normal controls (73 +/- 14 HU, p < 0.001). The attenuation difference between infarcted and remote myocardia was larger in patients with long-standing MI than in patients with recent MI (89 +/- 41 and 55 +/- 33 HU, respectively, p < 0.001). In addition, long-standing MI was associated with wall thinning (p < 0.01), and ventricular dilation (p < 0.05), whereas recent MI was not (p > 0.05). In conclusion, recent and long-standing MIs may be differentiated by computed tomography based on myocardial CT attenuation values and ventricular dimensions.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9149
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16860013-Coronary Angiography,
pubmed-meshheading:16860013-Disease Progression,
pubmed-meshheading:16860013-Female,
pubmed-meshheading:16860013-Follow-Up Studies,
pubmed-meshheading:16860013-Heart Ventricles,
pubmed-meshheading:16860013-Humans,
pubmed-meshheading:16860013-Male,
pubmed-meshheading:16860013-Middle Aged,
pubmed-meshheading:16860013-Myocardial Infarction,
pubmed-meshheading:16860013-Reproducibility of Results,
pubmed-meshheading:16860013-Retrospective Studies,
pubmed-meshheading:16860013-Severity of Illness Index,
pubmed-meshheading:16860013-Time Factors,
pubmed-meshheading:16860013-Tomography, X-Ray Computed
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pubmed:year |
2006
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pubmed:articleTitle |
Differentiation of recent and chronic myocardial infarction by cardiac computed tomography.
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pubmed:affiliation |
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA. koennieman@hotmail.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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