Linked Life Data

16859412

Source:http://linkedlifedata.com/resource/pubmed/id/16859412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-7-24
pubmed:abstractText
Medial temporal lobe structures such as the hippocampus have been shown to play a critical role in mnemonic processes, with additional recruitment of the amygdala when memories contain emotional content. Thus far, studies that have examined the relationship between amygdala activity and memory have typically relied on emotional content of the kind that is rarely encountered in day-to-day interactions. The present event-related functional magnetic resonance imaging study investigates whether amygdala activity supports emotional memory during the more subtle social interactions that punctuate everyday life. Across four training sessions, subjects learned common first names for unfamiliar faces in the presence or absence of additional contextual information that was positive, negative, and neutral in valence (e.g., "Emily helps the homeless," "Bob is a deadbeat dad," "Eric likes carrots"). During scanning, subjects performed a yes/no recognition memory test on studied and novel faces. Results revealed a functional dissociation within the medial temporal lobe. Whereas a region within the right hippocampus responded strongly to all faces that had been paired with a description, regardless of its valence, activity in the right amygdala was uniquely sensitive to faces that had been previously associated with emotional descriptions (negative and positive > neutral). This pattern of activity in the amygdala was preserved even when the emotional contexts associated with faces could not be explicitly retrieved, suggesting a role for the amygdala in providing a nonspecific arousal indicator in response to viewing individuals with emotionally colored pasts.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0898-929X
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1253-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Dissociable medial temporal lobe contributions to social memory.
pubmed:affiliation
Dartmouth Collegen, NH 03755, USA. leah.somerville@dartmouth.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural