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rdf:type |
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lifeskim:mentions |
umls-concept:C0026764,
umls-concept:C0031715,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0205548,
umls-concept:C0334227,
umls-concept:C0684249,
umls-concept:C0805732,
umls-concept:C1335960,
umls-concept:C1366753,
umls-concept:C1548425,
umls-concept:C1883254
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pubmed:issue |
14 Pt 1
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|
pubmed:dateCreated |
2006-7-21
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pubmed:abstractText |
Excessive activity of the transcription factors known as signal transducers and activators of transcription (STAT) contributes to the development and progression of malignancy in many organs. It is, therefore, important to develop new drugs to control the STATs, particularly their phosphorylation state, which is required for their transcriptional activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4288-93
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16857804-Apoptosis,
pubmed-meshheading:16857804-Cell Line, Tumor,
pubmed-meshheading:16857804-Cell Proliferation,
pubmed-meshheading:16857804-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16857804-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16857804-Humans,
pubmed-meshheading:16857804-Imidazoles,
pubmed-meshheading:16857804-Immunoblotting,
pubmed-meshheading:16857804-Interleukin-6,
pubmed-meshheading:16857804-Lung Neoplasms,
pubmed-meshheading:16857804-Multiple Myeloma,
pubmed-meshheading:16857804-Oleanolic Acid,
pubmed-meshheading:16857804-Phosphorylation,
pubmed-meshheading:16857804-STAT Transcription Factors,
pubmed-meshheading:16857804-STAT5 Transcription Factor,
pubmed-meshheading:16857804-Signal Transduction,
pubmed-meshheading:16857804-Time Factors,
pubmed-meshheading:16857804-Transcription, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.
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pubmed:affiliation |
Dartmouth Medical School and Dartmouth College, Hanover, New Hampshire, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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