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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14 Pt 1
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pubmed:dateCreated |
2006-7-21
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pubmed:abstractText |
Specific activating mutations within the epidermal growth factor receptor (EGFR) identify a subset of non-small cell lung cancers with dramatic sensitivity to the specific tyrosine kinase inhibitors (TKI), gefitinib and erlotinib. Despite the abundant expression of EGFR protein in a broad range of epithelial cancers, EGFR mutations have not been reported in a substantial fraction of other cancers. Given recent reports of TKI-responsive cases of esophageal and pancreatic cancer, this study was designed to determine the prevalence of EGFR mutations in these gastrointestinal cancers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BellDaphne WDW,
pubmed-author:BranniganBrian WBW,
pubmed-author:ClarkJeff WJW,
pubmed-author:DriscollDavid RDR,
pubmed-author:FerryDavidD,
pubmed-author:FuchsCharles SCS,
pubmed-author:HaberDaniel ADA,
pubmed-author:HarrisPatricia LPL,
pubmed-author:HaserlatSara MSM,
pubmed-author:JankowskiJanuszJ,
pubmed-author:KulkeMatthew HMH,
pubmed-author:KwakEunice LEL,
pubmed-author:LauwersGregory YGY,
pubmed-author:MuirBethB,
pubmed-author:OkimotoRoss ARA,
pubmed-author:RyanDavid PDP,
pubmed-author:SettlemanJeffJ,
pubmed-author:SgroiDennis CDC,
pubmed-author:ThayerSarah PSP
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4283-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16857803-Adenocarcinoma,
pubmed-meshheading:16857803-Antineoplastic Agents,
pubmed-meshheading:16857803-Cell Transformation, Neoplastic,
pubmed-meshheading:16857803-DNA Mutational Analysis,
pubmed-meshheading:16857803-Esophageal Neoplasms,
pubmed-meshheading:16857803-Exons,
pubmed-meshheading:16857803-Genotype,
pubmed-meshheading:16857803-Humans,
pubmed-meshheading:16857803-Mutation,
pubmed-meshheading:16857803-Pancreatic Neoplasms,
pubmed-meshheading:16857803-Protein Structure, Tertiary,
pubmed-meshheading:16857803-Receptor, Epidermal Growth Factor
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pubmed:year |
2006
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pubmed:articleTitle |
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.
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pubmed:affiliation |
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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