Linked Life Data

16857299

Source:http://linkedlifedata.com/resource/pubmed/id/16857299

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
pubmed:issue
8
pubmed:dateCreated
2006-8-21
pubmed:abstractText
PURPOSE: Today, calcitonin assay is used for the diagnosis of thyroid medullary cancer in the context of nodular thyroid disease. Calcitonin is an excellent marker of thyroid medullary cancer but some hypercalcitoninemia can also be related to other diseases, such as renal failure, endocrine tumors other than thyroid medullary cancer and sometimes to C cell hyperplasia, which is a not well-defined situation. Recent studies contributed to define calcitoninemia thresholds, which guide decision and avoid excessive invasive treatment. CURRENT KNOWLEDGE AND KEY POINTS: After a brief reminder of physiological role of calcitonin and assays, the difficulties encountered in interpreting hypercalcitoninemia and its potential causes other than thyroid medullary cancer are addressed. Recent studies, on large series, now allow a better knowledge of specificity and sensitivity of calcitonin measurement in patients with nodular thyroid disease and a well-argued management. FUTURE PROSPECTS AND PROJECTS: In the future, calcitonin dosage will be ordered even more frequently, as some authors recommend it for the diagnosis of thyroid nodule. It is up to us to know how to use this remarkable marker, by considering all possible situations of benign hypercalcitoninemia and reserving aggressive treatments for patients who really need them.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0248-8663
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
610-5
pubmed:dateRevised
2011-1-12
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[How to interprete hypercalcitoninemia?].
pubmed:affiliation
Service d'endocrinologie-diabétologie-maladies métaboliques, CHRU de Reims, hôpital Robert-Debré, avenue du Général-Koenig, 51092 Reims cedex, France. nathalie.levybohbot@ch-epernay.fr
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Review