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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-3-5
|
| pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60842,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60843,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60844,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60845,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60846,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60847,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M76731,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M76732,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S78711,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S78713
|
| pubmed:abstractText |
A cosmid containing the human sequence HOX7, homologous to the murine Hox-7 gene, was isolated from a genomic library, and the positions of the coding sequences were determined by hybridization. DNA sequence analysis demonstrated two exons that code for a homeodomain-containing protein of 297 amino acids. The open reading frame is interrupted by a single intron of approximately 1.6 kb, the splice donor and acceptor sites of which conform to known consensus sequences. The human HOX7 coding sequence has a very high degree of identity with the murine Hox-7 cDNA. Within the homeobox, the two sequences share 94% identity at the DNA level, all substitutions being silent. This high level of sequence similarity is not confined to the homeodomain; overall the human and murine HOX7 gene products show 80% identity at the amino acid level. Both the 5' and 3' untranslated regions also show significant similarity to the murine gene, with 79 and 70% sequence identity, respectively. The sequence upstream of the coding sequence of exon 1 contains a GC-rich putative promoter region. There is no TATA box, but a CCAAT and numerous GC boxes are present. The region encompassing the promoter region, exon 1, and the 5' region of exon 2 have a higher than expected frequency of CpG dinucleotides; numerous sites for rare-cutter restriction enzymes are present, a characteristic of HTF islands.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
670-8
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:1685479-Amino Acid Sequence,
pubmed-meshheading:1685479-Animals,
pubmed-meshheading:1685479-Base Sequence,
pubmed-meshheading:1685479-Cloning, Molecular,
pubmed-meshheading:1685479-Consensus Sequence,
pubmed-meshheading:1685479-Cosmids,
pubmed-meshheading:1685479-DNA-Binding Proteins,
pubmed-meshheading:1685479-Exons,
pubmed-meshheading:1685479-Genes, Homeobox,
pubmed-meshheading:1685479-Homeodomain Proteins,
pubmed-meshheading:1685479-Humans,
pubmed-meshheading:1685479-Introns,
pubmed-meshheading:1685479-MSX1 Transcription Factor,
pubmed-meshheading:1685479-Mice,
pubmed-meshheading:1685479-Molecular Sequence Data,
pubmed-meshheading:1685479-Multigene Family,
pubmed-meshheading:1685479-Open Reading Frames,
pubmed-meshheading:1685479-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1685479-Restriction Mapping,
pubmed-meshheading:1685479-Sequence Homology, Nucleic Acid
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Structure and sequence of the human homeobox gene HOX7.
|
| pubmed:affiliation |
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College of Science, Technology, and Medicine, London, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|