Linked Life Data

16854724

Source:http://linkedlifedata.com/resource/pubmed/id/16854724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-7-20
pubmed:abstractText
Based on the difference in steric bulk around C12-C13 double bond, the two isomeric dihydroxy pentacyclic triterpenic acids viz: corsolic acid and maslinic acid have been quantitatively separated via their methyl esters by reacting with the bulky m-chloroperbenzoic acid. Corsolic acid methyl ester was obtained in pure form, whereas maslinic acid methyl ester was separated as 12-oxo derivative formed via its epoxide. Alkaline hydrolysis of corsolic acid methyl ester afforded the desired acid. This method was also found to work well with the isomeric amyrin mixture (alpha- and beta-), but not highly selective. The high selectivity of this method with corsolic maslinic acid system can be rationalized in terms of 2alpha-hydroxy functionality, which provides additional crowding around the double bond and completely prevented corsolic acid from its reaction with perbenzoic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1478-6419
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
946-52
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
An efficient chemical method for separation of corsolic acid from its isomeric maslinic acid.
pubmed:affiliation
Centre for Herbal Drugs, Regional Research Laboratory (CSIR), Bhubaneswar-751 013, India. uvmavadani@rrlbhu.res.in
pubmed:publicationType
Journal Article