Linked Life Data

1685437

Source:http://linkedlifedata.com/resource/pubmed/id/1685437

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-3-3
pubmed:abstractText
1. Effects of the hypnotic drug etomidate were studied with intracellular recordings of the identified neurons B1 to B4 of the buccal ganglia of Helix pomatia. 2. At threshold doses of 10 mumol/l, etomidate mainly affected interneuronal networks. 3. In concentrations above 200 mumol/l, the drug induced typical epileptic activities (paroxysmal depolarization shifts, PDS). Neurons B1 to B4 generated epileptic activities in differential concentration ranges. PDS were synchronized via electrical contacts. PDS could be blocked by the "calcium antagonist" verapamil but not by a block of chemical synaptic transmission. 4. In comparison with the epileptogenic drug pentylenetrazol, effective doses of etomidate to induce PDS were about 100 times lower.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0742-8413
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
579-87
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effects of the hypnotic drug etomidate in a model nervous system (Buccal ganglia, Helix pomatia).
pubmed:affiliation
Institut für Experimentelle Epilepsieforschung, Münster, F.R.G.
pubmed:publicationType
Journal Article, Comparative Study