Linked Life Data

1685436

Source:http://linkedlifedata.com/resource/pubmed/id/1685436

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-3-3
pubmed:abstractText
1. Response to the opioids of isolated small intestine of Suncus murinus, an insectivore, was examined and compared with that of guinea-pig ileum. 2. The mechanical response to morphine and U50,488H, preferential mu- and kappa-agonist respectively, was relaxation which was antagonized by tetrodotoxin and naloxone in the Suncus small intestine. 3. Methionine5-enkephalin and D-alanine2, D-leucine5-enkephalin, both preferential delta-agonists, elicited contraction or relaxation in the Suncus small intestine, while enkephalins elicited sustained contraction in the tetrodotoxin-pretreated intestine. 4. In the guinea-pig ileum, the response to morphine and enkephalins was consistently relaxation which was antagonized by tetrodotoxin and naloxone. 5. Morphine, D-alanine2,D-leucine5-enkephalin and U50,488H inhibited electrically-evoked twitch responses of intestine in a concentration-dependent manner in both animals. 6. The relative potencies calculated from IC50 values of opioids for twitches followed the order, D-alanine2,D-leucine5-enkephalin greater than U50,488H greater than morphine in the Suncus small intestine, whereas U50,488 greater than D-alanine2,D-leucine5-enkephalin greater than morphine in the guinea-pig ileum. 7. Suncus small intestine has unique features such that D-alanine2,D-leucine5-enkephalin was most potent in inhibiting electrically-evoked twitches and that enkephalins induced contraction following tetrodotoxin pretreatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0742-8413
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
573-8
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed-meshheading:1685436-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz..., pubmed-meshheading:1685436-Analgesics, pubmed-meshheading:1685436-Animals, pubmed-meshheading:1685436-Electric Stimulation, pubmed-meshheading:1685436-Enkephalin, Leucine-2-Alanine, pubmed-meshheading:1685436-Guinea Pigs, pubmed-meshheading:1685436-Ileum, pubmed-meshheading:1685436-Intestine, Small, pubmed-meshheading:1685436-Male, pubmed-meshheading:1685436-Morphine, pubmed-meshheading:1685436-Muscle, Smooth, pubmed-meshheading:1685436-Muscle Contraction, pubmed-meshheading:1685436-Pyrrolidines, pubmed-meshheading:1685436-Receptors, Opioid, pubmed-meshheading:1685436-Receptors, Opioid, delta, pubmed-meshheading:1685436-Receptors, Opioid, kappa, pubmed-meshheading:1685436-Receptors, Opioid, mu, pubmed-meshheading:1685436-Shrews
pubmed:year
1991
pubmed:articleTitle
Response to opioids of isolated small intestine in the house musk shrew, Suncus murinus.
pubmed:affiliation
Department of Pharmacology, Tokyo Women's Medical College, Japan.
pubmed:publicationType
Journal Article, Comparative Study