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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1992-2-24
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pubmed:abstractText |
The rate of erythrocyte Li-Na countertransport and cellular Na+ and K+ contents have been determined in normotensive (NT) and hypertensive (HT, essential hypertension) subjects in the presence and absence of atrial natriuretic peptide (ANP). The rate of Li-Na countertransport was significantly higher in erythrocytes of HT subjects, while the Na+ and K+ contents were not different between the NT and HT groups. We found that ANP (10(-9) and 10(-7) M) had no effect on either the rate of Li-Na countertransport or the cellular Na+ and K+ contents. Since ANP does not influence erythrocyte Na pump and Na-K-Cl cotransport, our results suggest that the Na transport systems of human erythrocytes do not respond to ANP and this lack of response in Li-Na countertransport is independent of the status of hypertension. These findings are consistent with the view that the rate of Li-Na countertransport of erythrocytes may serve as a useful genetic marker for essential hypertension in Chinese. However, the erythrocyte transport systems cannot provide further differentiation utilizing ANP response for essential hypertension.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiporters,
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-lithium countertransporter
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0929-6646
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1022-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1685169-Adult,
pubmed-meshheading:1685169-Antiporters,
pubmed-meshheading:1685169-Atrial Natriuretic Factor,
pubmed-meshheading:1685169-Biological Markers,
pubmed-meshheading:1685169-Carrier Proteins,
pubmed-meshheading:1685169-China,
pubmed-meshheading:1685169-Erythrocytes,
pubmed-meshheading:1685169-Humans,
pubmed-meshheading:1685169-Hypertension,
pubmed-meshheading:1685169-Middle Aged,
pubmed-meshheading:1685169-Potassium
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pubmed:year |
1991
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pubmed:articleTitle |
Erythrocyte Li-Na countertransport in hypertension: lack of atrial natriuretic peptide effect.
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pubmed:affiliation |
Department of Physiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, R.O.C.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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