Linked Life Data

16850610

Source:http://linkedlifedata.com/resource/pubmed/id/16850610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-7-20
pubmed:abstractText
In recent years, the term "conformational disease" has been used to describe a range of disorders which are linked to misfolding and aberrant structural change in proteins. The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed, and almost all of the diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease and prion disease are increasingly being realized to have common molecular mechanisms including the accumulation of misfolded or aggregation-prone proteins, thus, they can be termed "neurodegenerative conformational disease". There is now increased understanding of the molecular pathways involved in protein misfolding and aggregation and cellular toxicity in neurodegenerative conformational diseases. These are leading to approaches toward rational therapeutics.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0559-7765
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-102
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Neurodegenerative conformational disease and its molecular bases].
pubmed:affiliation
Laboratory for Neurological Research of Institute of Integrative Medicine, Zhongshan Hospital, China.
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't