Source:http://linkedlifedata.com/resource/pubmed/id/16850495
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rdf:type | |
lifeskim:mentions |
umls-concept:C0021344,
umls-concept:C0041904,
umls-concept:C0079904,
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umls-concept:C1299583,
umls-concept:C1549571,
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umls-concept:C1608386,
umls-concept:C1704787,
umls-concept:C2698872
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pubmed:issue |
8
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pubmed:dateCreated |
2006-7-24
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pubmed:abstractText |
Nuclear factor-kappaB (NF-kappaB) has a pivotal function in controlling a wide variety of gene functions, and has shown to be constitutively activated in many human cancers. The molecular links of NF-kappaB to oncogenic human papillomavirus (HPV) in cervical intraepithelial neoplasia (CIN) lesions and its prognostic value in cervical cancer (CC) are incompletely understood. As part of our HPV-PathogenISS study, a series of 150 squamous-cell carcinomas (SCCs) and 152 CIN lesions were examined using immunohistochemical staining for NF-kappaB, and tested for HPV using PCR with three primer sets (MY09/11, GP5+/GP6+, and SPF). Follow-up data were available from all SCC patients, and 67 CIN lesions had been monitored with serial PCR for HPV clearance/persistence after cone treatment. Cytoplasmic NF-kappaB expression was associated with CIN3/cancer at OR 3.55 (95% CI, 1.79-7.05), while nuclear NF-kappaB expression had an OR of 21.90 (95% CI, 2.96-161.74) (P = 0.0001). Strong nuclear expression was a rare event (8.8%) also in CC, but it was related to high-risk human papillomavirus (HR-HPV) detection, with OR 2.15 (95% CI, 1.08-4.30) (P = 0.022). This association was confounded, however, by the histological grade (Mantel-Haenszel common OR = 1.46; 95% CI, 0.70-3.03) (P = 0.308). Cytoplasmic or nuclear NF-kappaB expression did not predict clearance/persistence of HR-HPV after treatment of CIN, and neither one proved to be a prognostic predictor in CC. Overexpression of cytoplasmic NF-kappaB is significantly associated with progression to CIN3 and cancer. This is paralleled by only a slight increase in nuclear expression of NF-kappaB, which could be explained by the mechanisms whereby HR-HPVs escape from the transcriptional control of NF-kappaB, i.e., E7-mediated impaired nuclear translocation of cytoplasmic NF-kappaB, and E6-conditioned attenuated NF-kappaB (p65)-dependent transcriptional activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
8755-1039
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pubmed:author |
pubmed-author:AccardiLL,
pubmed-author:BenedettoAA,
pubmed-author:BonifacioDD,
pubmed-author:BrancaMM,
pubmed-author:CiottiMM,
pubmed-author:CostaSS,
pubmed-author:Di BonitoLL,
pubmed-author:Di BonitoPP,
pubmed-author:FavalliCC,
pubmed-author:GiorgiCC,
pubmed-author:HPV-Pthogen ISS Study Group,
pubmed-author:MarianiLL,
pubmed-author:PabaPP,
pubmed-author:RuutuMM,
pubmed-author:SantiniDD,
pubmed-author:SyrjänenKK,
pubmed-author:SyrjänenSS
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pubmed:copyrightInfo |
(c) 2006 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
555-63
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pubmed:meshHeading |
pubmed-meshheading:16850495-Adolescent,
pubmed-meshheading:16850495-Adult,
pubmed-meshheading:16850495-Aged,
pubmed-meshheading:16850495-Alphapapillomavirus,
pubmed-meshheading:16850495-Carcinoma, Squamous Cell,
pubmed-meshheading:16850495-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:16850495-Female,
pubmed-meshheading:16850495-Humans,
pubmed-meshheading:16850495-Middle Aged,
pubmed-meshheading:16850495-NF-kappa B,
pubmed-meshheading:16850495-Neoplasm Staging,
pubmed-meshheading:16850495-Papillomavirus Infections,
pubmed-meshheading:16850495-Polymerase Chain Reaction,
pubmed-meshheading:16850495-Risk Assessment,
pubmed-meshheading:16850495-Up-Regulation,
pubmed-meshheading:16850495-Uterine Cervical Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
Upregulation of nuclear factor-kappaB (NF-kappaB) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus or disease outcome in cervical cancer.
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pubmed:affiliation |
Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità (ISS), Rome, Italy.
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pubmed:publicationType |
Journal Article
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