| pubmed-article:16849446 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C0026918 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:16849446 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:16849446 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16849446 | pubmed:dateCreated | 2006-7-19 | lld:pubmed |
| pubmed-article:16849446 | pubmed:abstractText | T cell responses are important to the control of infection but are deleterious if not regulated. IFN-gamma-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-gamma-deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Guérin. Furthermore, exogenous IFN-gamma increases IL-12 and decreases IL-23 production by bacille Calmette Guérin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-gamma- and IL-17-producing T cells are induced, but that IFN-gamma serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune-mediated pathology. | lld:pubmed |
| pubmed-article:16849446 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16849446 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16849446 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16849446 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16849446 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16849446 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16849446 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:CooperAndrea... | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:CruzAndreaA | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:PearlJohn EJE | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:KhaderShabaan... | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:CastroAntónio... | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:PedrosaJorgeJ | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:TorradoEgidio... | lld:pubmed |
| pubmed-article:16849446 | pubmed:author | pubmed-author:FragaAlexandr... | lld:pubmed |
| pubmed-article:16849446 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16849446 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16849446 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:16849446 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16849446 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16849446 | pubmed:pagination | 1416-20 | lld:pubmed |
| pubmed-article:16849446 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16849446 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16849446 | pubmed:articleTitle | Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. | lld:pubmed |
| pubmed-article:16849446 | pubmed:affiliation | Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal. | lld:pubmed |
| pubmed-article:16849446 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16849446 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16849446 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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