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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-7-19
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pubmed:abstractText |
T cell responses are important to the control of infection but are deleterious if not regulated. IFN-gamma-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-gamma-deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Guérin. Furthermore, exogenous IFN-gamma increases IL-12 and decreases IL-23 production by bacille Calmette Guérin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-gamma- and IL-17-producing T cells are induced, but that IFN-gamma serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune-mediated pathology.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1416-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16849446-Animals,
pubmed-meshheading:16849446-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16849446-Cell Differentiation,
pubmed-meshheading:16849446-Cell Proliferation,
pubmed-meshheading:16849446-Cells, Cultured,
pubmed-meshheading:16849446-Dendritic Cells,
pubmed-meshheading:16849446-Growth Inhibitors,
pubmed-meshheading:16849446-Interferon-gamma,
pubmed-meshheading:16849446-Interleukin-12,
pubmed-meshheading:16849446-Interleukin-17,
pubmed-meshheading:16849446-Interleukin-23,
pubmed-meshheading:16849446-Interleukin-23 Subunit p19,
pubmed-meshheading:16849446-Interleukins,
pubmed-meshheading:16849446-Male,
pubmed-meshheading:16849446-Mice,
pubmed-meshheading:16849446-Mice, Inbred C57BL,
pubmed-meshheading:16849446-Mice, Knockout,
pubmed-meshheading:16849446-Mice, Transgenic,
pubmed-meshheading:16849446-Mycobacterium bovis,
pubmed-meshheading:16849446-Tuberculosis
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pubmed:year |
2006
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pubmed:articleTitle |
Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection.
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pubmed:affiliation |
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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