Linked Life Data

16849394

Source:http://linkedlifedata.com/resource/pubmed/id/16849394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-8-25
pubmed:abstractText
Dental caries and pulpitis are the most common bacterial infections in humans. However, the immune responses against bacterial stimulation in dental pulp that is bounded by special hard tissues are poorly understood. We examined the initial immune responses in mouse dental pulp after cusp trimming and acid treatment. Using fluorescence immunohistochemistry, two distinct cell populations were identified in the intact pulp; CD11c+F4/80- and CD11c-F4/80+ cells. CD11c+F4/80- cells were localized in the pulp-dentin (P-D) border of the central pulp beneath the dental fissure, whereas CD11c-F4/80+ cells with dendritic morphology were distributed in the perivascular region of the inner pulp and the sub-odontoblastic layer. CD11c+F4/80- cells, but not CD11c-F4/80+ cells, constitutively expressed toll-like receptors 2 and 4 and CD205, and migrated to the P-D border of the treated side within 2 h after the treatment. In parallel, some of the F4/80+ cells migrated to the inner pulp of the treated side, increased in size and enhanced CD86 expression. At 24 h, the CD86+ cells with high fluorescence intensity had disappeared entirely from the pulp. Concurrently, CD86high cells expressing intermediate levels of CD11c and high levels of MHC class II and F4/80, assessed by using flow cytometry, increased significantly in the regional lymph nodes, suggesting migration of these cells from the dental pulp. Our results are the first to demonstrate the existence of at least two types of dendritic cells (DCs) in dental pulp. The CD11c+ sentinel and F4/80+ interstitial DCs might have distinct territories and unique roles in responding to external stimuli via the dentinal tubules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1375-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.
pubmed:affiliation
Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't