16848979

Source:http://linkedlifedata.com/resource/pubmed/id/16848979

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006826, umls-concept:C0205169, umls-concept:C0205170, umls-concept:C2717878
pubmed:issue	6
pubmed:dateCreated	2006-7-19
pubmed:abstractText	For some time, investigators have appreciated that genetic association studies in cancer are complex because of the multi-stage process of cancer and the daunting challenge of analysing genetic variants in population and family studies. Because of recent technological advances and annotation of common genetic variation in the human genome, it is now possible for investigators to study genetic variation and cancer risk in many different settings. While these studies hold great promise for unravelling multiple genetic risk factors that contribute to the set of complex diseases called cancer, it is also imperative that study design and methods of interpretation be carefully considered. Replication of results in sufficiently large, well-powered studies is critical if genetic variation is to realise the promise of personalised medicine--namely, using genetic data to individualise medical decisions. In this regard, the plausibility of validated genetic variants can only be realised by the study of gene-gene and gene-environment interactions. The genetic association study in cancer has come a long way from the days of restriction fragment length polymorphisms, and now promises to scan an entire genome 'agnostically' in search of genetic markers for a disease or outcome. Moreover, the application and interpretation of these studies should be conducted cautiously.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101202210
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1479-7364
pubmed:author	pubmed-author:ChanockStephen JSJ, pubmed-author:SavageSharon ASA
pubmed:issnType	Electronic
pubmed:volume	2
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	415-21
pubmed:dateRevised	2007-2-14
pubmed:meshHeading	pubmed-meshheading:16848979-Genetic Predisposition to Disease, pubmed-meshheading:16848979-Humans, pubmed-meshheading:16848979-Neoplasms
pubmed:year	2006
pubmed:articleTitle	Genetic association studies in cancer: good, bad or no longer ugly?
pubmed:affiliation	Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType	Journal Article, Review