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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1992-2-11
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pubmed:abstractText |
Rapid inhibition of acetyl-CoA carboxylase (ACC) activity in rat liver in response to 6 h starvation and rapid re-activation in response to 2-6 h of re-feeding chow were shown to be due to changes in the expressed activity of existing enzyme. Decreases and increases in ACC concentration occurred at later stages of the transitions, i.e. 6-48 h starvation and 8-24 h re-feeding respectively. The decrease in expressed activity of ACC was due primarily to changes in its phosphorylation state, demonstrated by a significantly decreased Vmax. and significantly increased Ka for citrate of enzyme purified by avidin-Sepharose chromatography from 6 h- or 48 h-starved rats. These effects were totally reversed within 2-4 h of chow re-feeding. Changes in the activity of purified ACC closely correlated with reciprocal changes in the activity of AMP-activated protein kinase (AMP-PK) over the fed to starved to re-fed transition. Increases in the activity ratio of cyclic-AMP-dependent protein kinase in response to starvation lagged behind the increase in AMP-PK and the decrease in ACC activity. Changes in AMP-PK and ACC activities of rat liver closely correlated with changes in plasma insulin concentration in response to time courses of starvation and re-feeding.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-1688796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-1967580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-1980063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-200176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2264816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2426266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2569864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2575259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2879530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2884991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2889619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2896194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2898386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2899891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2900138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-2900158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-3415654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-3426553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-3541753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-4146037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-4981792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-6303789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-6316096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1684893-6479340
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
280 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1684893-AMP-Activated Protein Kinases,
pubmed-meshheading:1684893-Acetyl-CoA Carboxylase,
pubmed-meshheading:1684893-Animals,
pubmed-meshheading:1684893-Enzyme Stability,
pubmed-meshheading:1684893-Female,
pubmed-meshheading:1684893-Insulin,
pubmed-meshheading:1684893-Liver,
pubmed-meshheading:1684893-Multienzyme Complexes,
pubmed-meshheading:1684893-Polyethylene Glycols,
pubmed-meshheading:1684893-Protein Kinases,
pubmed-meshheading:1684893-Protein-Serine-Threonine Kinases,
pubmed-meshheading:1684893-Rats,
pubmed-meshheading:1684893-Starvation
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pubmed:year |
1991
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pubmed:articleTitle |
The short-term regulation of hepatic acetyl-CoA carboxylase during starvation and re-feeding in the rat.
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pubmed:affiliation |
Department of Pharmaceutical Chemistry, School of Pharmacy, London, U.K.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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