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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0205178,
umls-concept:C0314603,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0600688,
umls-concept:C0851238,
umls-concept:C1522449,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2603343,
umls-concept:C2698872
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pubmed:issue |
4
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pubmed:dateCreated |
2007-1-16
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pubmed:abstractText |
The cytotoxic effects of radiation therapy are mediated primarily through increased formation of hydroxyl radicals and reactive oxygen species, which can damage cells, proteins and DNA; the glutathione S-transferases (GSTs) function to protect against oxidative stress. We hypothesized that polymorphisms encoding reduced or absent activity in the GSTs might result in greater risk for radiation-associated toxicity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-10517533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-10799730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-10820347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-11059750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-11297249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-11535243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-12042665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-12654430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-14643951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-15025930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-15368334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-15528046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-15565566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-15788664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-16000570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-16000577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-1938553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-3883167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-7925413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-8619490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-8871000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-8985028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-9150188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16848913-9559871
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-542X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R40
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pubmed:dateRevised |
2010-9-16
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pubmed:meshHeading |
pubmed-meshheading:16848913-Adult,
pubmed-meshheading:16848913-Aged,
pubmed-meshheading:16848913-Breast Neoplasms,
pubmed-meshheading:16848913-Female,
pubmed-meshheading:16848913-Genotype,
pubmed-meshheading:16848913-Glutathione S-Transferase pi,
pubmed-meshheading:16848913-Humans,
pubmed-meshheading:16848913-Mastectomy, Segmental,
pubmed-meshheading:16848913-Middle Aged,
pubmed-meshheading:16848913-Oxidative Stress,
pubmed-meshheading:16848913-Polymorphism, Genetic,
pubmed-meshheading:16848913-Predictive Value of Tests,
pubmed-meshheading:16848913-Prospective Studies,
pubmed-meshheading:16848913-Radiation Dosage,
pubmed-meshheading:16848913-Radiodermatitis,
pubmed-meshheading:16848913-Radiotherapy
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pubmed:year |
2006
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pubmed:articleTitle |
Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study.
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pubmed:affiliation |
Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York, USA. christine.ambrosone@roswellpark.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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