Linked Life Data

16847310

Source:http://linkedlifedata.com/resource/pubmed/id/16847310

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-9-29
pubmed:abstractText
The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA levels of nuclear hormone receptors [peroxisome proliferator-activated receptor gamma (PPARgamma), liver X receptor alpha (LXRalpha) and LXRbeta, thyroid receptor alpha (TRalpha) and TRbeta, and retinoid X receptor alpha (RXRalpha) and RXRbeta] and receptor coactivators [cAMP response element binding protein, steroid receptor coactivator 1 (SRC1) and SRC2, thyroid hormone receptor-associated protein, and peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC1alpha) and PGC1beta] along with decreased expression of target genes (adipocyte P2, phosphoenolpyruvate carboxykinase, glycerol-3-phosphate acyltransferase, ABCA1, apolipoprotein E, sterol-regulatory element binding protein-1c, glucose transport protein 4 (GLUT4), malic enzyme, and Spot14) involved in triglyceride (TG) and carbohydrate metabolism. We show that key TG synthetic enzymes, 1-acyl-sn-glycerol-3-phosphate acyltransferase-2, monoacylglycerol acyltransferase 1, and diacylglycerol acyltransferase 1, are PPARgamma-regulated genes and that they also decrease in the APR. In 3T3-L1 adipocytes, tumor necrosis factor-alpha (TNF-alpha) significantly decreases PPARgamma, LXRalpha and LXRbeta, RXRalpha and RXRbeta, SRC1 and SRC2, and PGC1alpha and PGC1beta mRNA levels, which are associated with a marked reduction in receptor-regulated genes. Moreover, TNF-alpha significantly reduces PPAR and LXR response element-driven transcription. Thus, the APR suppresses the expression of many nuclear hormone receptors and their coactivators in adipose tissue, which could be a mechanism to coordinately downregulate TG biosynthesis and thereby redirect lipids to other critical organs during the APR.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2179-90
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16847310-Acute-Phase Reaction, pubmed-meshheading:16847310-Acyltransferases, pubmed-meshheading:16847310-Adipocytes, pubmed-meshheading:16847310-Adipose Tissue, pubmed-meshheading:16847310-Animals, pubmed-meshheading:16847310-Cells, Cultured, pubmed-meshheading:16847310-DNA-Binding Proteins, pubmed-meshheading:16847310-Female, pubmed-meshheading:16847310-Gene Expression Regulation, pubmed-meshheading:16847310-Lipopolysaccharides, pubmed-meshheading:16847310-Mice, pubmed-meshheading:16847310-Mice, Inbred C57BL, pubmed-meshheading:16847310-Orphan Nuclear Receptors, pubmed-meshheading:16847310-PPAR gamma, pubmed-meshheading:16847310-RNA, Messenger, pubmed-meshheading:16847310-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:16847310-Transcription, Genetic, pubmed-meshheading:16847310-Tumor Necrosis Factor-alpha, pubmed-meshheading:16847310-Zymosan
pubmed:year
2006
pubmed:articleTitle
Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.
pubmed:affiliation
Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural