Linked Life Data

16845176

Source:http://linkedlifedata.com/resource/pubmed/id/16845176

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-7-17
pubmed:abstractText
Minibrain-related kinase (Mirk)/dual-specificity tyrosine-regulated kinase (Dyrk)1B is one of the best functionally characterized members of the Dyrk/Minibrain family of dual-specificity kinases. Dyrk family kinases are highly conserved mediators of growth control and differentiation. Mirk is expressed at high levels in skeletal muscle; thus, most of the recent studies of Mirk have used myogenesis as a model system to explore the function of Mirk in a native physiological environment. These studies have revealed that Mirk is a multifunctional Ser/Thr kinase that plays a critical role in muscle differentiation by regulatory effects on motility, transcription, cell cycle progression, and cell survival. Mirk also is found at elevated levels in various solid tumors, where it seems to act as a tumor survival factor. This review summarizes the known regulators and functions of Mirk kinase and outlines opportunities for future studies of Mirk in the fields of muscle and tumor biology.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1085-9195
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-15
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.
pubmed:affiliation
Department of Pathology, Upstate Medical University, SUNY, 750 East Adams Street, Syracuse, NY 13210, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural