Linked Life Data

16843572

Source:http://linkedlifedata.com/resource/pubmed/id/16843572

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-6-1
pubmed:abstractText
Cluster analysis of water-maze reference-memory performance distinguished subpopulations of young adult (3-5 months), aged (25-27 months) unimpaired (AU) and aged impaired (AI) rats. Working-memory performances of AU and AI rats were close to normal (though young and aged rats differed in exploration strategies). All aged rats showed impaired procedural-memory. Electrically evoked release of tritium was assessed in striatal slices (preloaded with [(3)H]choline) in the presence of oxotremorine, physostigmine, atropine+physostigmine, quinpirole, nomifensine or sulpiride. Aged rats exhibited reduced accumulation of [(3)H]choline (-30%) and weaker transmitter release. Drug effects (highest concentration) were reductions of release by 44% (oxotremorine), 72% (physostigmine), 84% (quinpirole) and 65% (nomifensine) regardless of age. Sulpiride and atropine+physostigmine facilitated the release more efficiently in young rats versus aged rats. The sulpiride-induced facilitation was weaker in AI rats versus AU rats; it significantly correlated with reference-memory performance. The results confirm age-related alterations of cholinergic and dopaminergic striatal functions, and point to the possibility that alterations in the D(2)-mediated dopaminergic regulation of these functions contribute to age-related reference-memory deficits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1558-1497
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1270-85
pubmed:meshHeading
pubmed-meshheading:16843572-Acetylcholine, pubmed-meshheading:16843572-Age Factors, pubmed-meshheading:16843572-Aging, pubmed-meshheading:16843572-Animals, pubmed-meshheading:16843572-Behavior, Animal, pubmed-meshheading:16843572-Cholinesterase Inhibitors, pubmed-meshheading:16843572-Corpus Striatum, pubmed-meshheading:16843572-Dopamine Agonists, pubmed-meshheading:16843572-Dopamine Antagonists, pubmed-meshheading:16843572-Dopamine Uptake Inhibitors, pubmed-meshheading:16843572-Electric Stimulation, pubmed-meshheading:16843572-Female, pubmed-meshheading:16843572-Maze Learning, pubmed-meshheading:16843572-Memory, pubmed-meshheading:16843572-Muscarinic Agonists, pubmed-meshheading:16843572-Nomifensine, pubmed-meshheading:16843572-Oxotremorine, pubmed-meshheading:16843572-Physostigmine, pubmed-meshheading:16843572-Quinpirole, pubmed-meshheading:16843572-Rats, pubmed-meshheading:16843572-Rats, Long-Evans, pubmed-meshheading:16843572-Sulpiride
pubmed:year
2007
pubmed:articleTitle
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices.
pubmed:affiliation
Laboratoire de Neurosciences Comportementales et Cognitives, FRE 2855, CNRS-Université Louis Pasteur, IFR 37 Neurosciences, GDR CNRS 2905, Strasbourg, France. jean-christophe.cassel@psycho-ulp.u-strasbg.fr
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't