Source:http://linkedlifedata.com/resource/pubmed/id/16843446
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-8-28
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| pubmed:abstractText |
E-selectin, which is a member of the selectin superfamily of adhesion molecules, contributes to the leukocyte-endothelial cell attachments and is involved in the pathogenesis of thrombovascular diseases as a consequence. We investigated the A561C mutation in the E-selectin gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 301 age- and sex-matched healthy controls. Excluding the subjects with diabetes mellitus and hypercholesterolemia, the AC genotype frequencies of patients with ischemic CVD were higher than those of controls: 12.7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
7
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| pubmed:volume |
1108
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
221-3
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| pubmed:meshHeading |
pubmed-meshheading:16843446-Aged,
pubmed-meshheading:16843446-Brain Ischemia,
pubmed-meshheading:16843446-Cell Adhesion,
pubmed-meshheading:16843446-Cerebral Arteries,
pubmed-meshheading:16843446-Cerebrovascular Disorders,
pubmed-meshheading:16843446-Chemotaxis, Leukocyte,
pubmed-meshheading:16843446-Diabetes Complications,
pubmed-meshheading:16843446-E-Selectin,
pubmed-meshheading:16843446-Female,
pubmed-meshheading:16843446-Genetic Predisposition to Disease,
pubmed-meshheading:16843446-Humans,
pubmed-meshheading:16843446-Hypercholesterolemia,
pubmed-meshheading:16843446-Intracranial Thrombosis,
pubmed-meshheading:16843446-Japan,
pubmed-meshheading:16843446-Male,
pubmed-meshheading:16843446-Middle Aged,
pubmed-meshheading:16843446-Polymorphism, Genetic,
pubmed-meshheading:16843446-Risk Factors
|
| pubmed:year |
2006
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| pubmed:articleTitle |
A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia.
|
| pubmed:affiliation |
Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160-8582, Japan. hidehatt@1999.jukuin.keio.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|