|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011854,
umls-concept:C0023820,
umls-concept:C0023823,
umls-concept:C0086418,
umls-concept:C0225336,
umls-concept:C0311404,
umls-concept:C0332307,
umls-concept:C0681850,
umls-concept:C1280500,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1883709,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
7
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pubmed:dateCreated |
2006-7-17
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pubmed:abstractText |
Homocysteine (Hcy) is an independent risk factor for cardiovascular disease (CVD). Individuals with Type 1 and Type 2 diabetes are more susceptible to the effects of homocysteine than non-diabetic subjects. The interaction between homocysteine-thiolactone (Hcy-thiolactone), a reactive product of Hcy, and low-density lipoproteins (LDL) induces the formation of homocystamide-LDL adducts (Hcy-LDL) and it has been suggested that homocysteinylation could increase atherogenicity of lipoproteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0742-3071
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
808-13
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pubmed:meshHeading |
pubmed-meshheading:16842488-Adult,
pubmed-meshheading:16842488-Aorta,
pubmed-meshheading:16842488-Atherosclerosis,
pubmed-meshheading:16842488-Diabetes Mellitus, Type 1,
pubmed-meshheading:16842488-Endothelial Cells,
pubmed-meshheading:16842488-Homocysteine,
pubmed-meshheading:16842488-Humans,
pubmed-meshheading:16842488-Lipoproteins, LDL,
pubmed-meshheading:16842488-Male,
pubmed-meshheading:16842488-Peroxynitrous Acid,
pubmed-meshheading:16842488-Radiation-Protective Agents
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pubmed:year |
2006
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pubmed:articleTitle |
Homocysteinylation of low-density lipoproteins (LDL) from subjects with Type 1 diabetes: effect on oxidative damage of human endothelial cells.
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pubmed:affiliation |
Istituto of Biochimica, Facoltà di Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy. g.ferretti@univpm.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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