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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1992-1-23
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pubmed:abstractText |
To determine if effector subsets exist among human gamma/delta T cells, we examined the cytokine production and cytotoxic activity of gamma/delta T cell clones with different accessory molecule phenotypes, V delta and V gamma gene expression, and J gamma rearrangements. T cell clones bearing gamma/delta T cell receptor produce an array of cytokines like alpha/beta T cell clones. Individual gamma/delta T cell clones produced a characteristic array of cytokines without correlation with V delta or V gamma gene expression. However, when phenotypic subsets were considered, CD4+ gamma/delta clones produced significantly higher levels of interleukin 2 and granulocyte-monocyte colony-stimulating factor compared with CD4-CD8- and CD8+ gamma/delta clones. Similarly, when cytotoxic potential was assessed, CD4+ gamma/delta clones exhibited minimal activity when compared with CD4-CD8- and CD8+ adult peripheral blood gamma/delta clones. We conclude that functionally distinct gamma/delta T cell subsets exist and suggest that these subsets may correlate with expression of the CD4 accessory molecule.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2999-3007
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1684157-Amino Acid Sequence,
pubmed-meshheading:1684157-Antigens, CD8,
pubmed-meshheading:1684157-Base Sequence,
pubmed-meshheading:1684157-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1684157-Clone Cells,
pubmed-meshheading:1684157-Cytokines,
pubmed-meshheading:1684157-Cytotoxicity, Immunologic,
pubmed-meshheading:1684157-Flow Cytometry,
pubmed-meshheading:1684157-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:1684157-Humans,
pubmed-meshheading:1684157-Immunity, Cellular,
pubmed-meshheading:1684157-Interleukin-2,
pubmed-meshheading:1684157-Liver,
pubmed-meshheading:1684157-Molecular Sequence Data,
pubmed-meshheading:1684157-Oligodeoxyribonucleotides,
pubmed-meshheading:1684157-Polymerase Chain Reaction,
pubmed-meshheading:1684157-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:1684157-T-Lymphocyte Subsets,
pubmed-meshheading:1684157-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1684157-Tumor Necrosis Factor-alpha
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pubmed:year |
1991
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pubmed:articleTitle |
Functionally distinct subsets of human gamma/delta T cells.
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pubmed:affiliation |
Laboratory of Immunochemistry, Dana Farber Cancer Institute, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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