Source:http://linkedlifedata.com/resource/pubmed/id/16841028
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2006-7-14
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pubmed:abstractText |
We report the intramedullary growth of a malignant peripheral nerve sheath tumour (MPNST). A 50year-old man developed a severe tetraparesis over a 4-month period. Following irradiation of a chronic tonsillitis during his childhood, the patient had later experienced a number of post-radiation diseases, including a laryngeal cancer that required permanent tracheotomy. Before admission, a magnetic resonance imaging (MRI) study had disclosed a C4-C5 intramedullary lesion. On admission to our Department, the patient had a nearly complete tetraparesis. At surgery, the lesion was exposed through a posterior midline myelotomy. A friable neoplasm, with no clear plane of cleavage, was found. The tumour was subtotally resected. Histological examination, which intraoperatively had not yielded a specific diagnosis, eventually revealed a MPNST, grade intermediate, with ultrastructural and immunohistochemical features consistent with a schwannian differentiation. No postoperative radiotherapy was undertaken. The patient died 9 months later from pneumonial complications. MPNSTs may develop within the spinal cord similarly to their benign schwannian counterpart. The reported sequence of events might support a possible relation between irradiation of the spinal cord and induction, followed by malignant transformation, of intramedullary schwannosis. This unique case must be added to the growing list of radiation-induced spinal cord tumours.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0390-5616
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-53
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pubmed:meshHeading |
pubmed-meshheading:16841028-Cell Movement,
pubmed-meshheading:16841028-Cell Transformation, Neoplastic,
pubmed-meshheading:16841028-Humans,
pubmed-meshheading:16841028-Male,
pubmed-meshheading:16841028-Middle Aged,
pubmed-meshheading:16841028-Neoplasms, Radiation-Induced,
pubmed-meshheading:16841028-Nerve Sheath Neoplasms,
pubmed-meshheading:16841028-Radiotherapy,
pubmed-meshheading:16841028-Schwann Cells,
pubmed-meshheading:16841028-Spinal Cord Neoplasms,
pubmed-meshheading:16841028-Tonsillitis
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pubmed:year |
2006
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pubmed:articleTitle |
Post-radiation intramedullary malignant peripheral nerve sheath tumor.
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pubmed:affiliation |
Division of Neurosurgery, IRCCS Neuromed Pozzilli, Uiversity of Perugia, Italy. spao2@yahoo.com
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pubmed:publicationType |
Journal Article,
Case Reports
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