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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-18
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pubmed:abstractText |
Oxidative stress (OS) induces smooth muscle cell apoptosis in the atherosclerotic plaque, leading to plaque instability and rupture. Heme oxygenase-1 (HO-1) exerts cytoprotective effects in the vessel wall. Recent evidence suggests that PKB/Akt may modulate HO-1 activity. This study examined the role of Akt in mediating the cytoprotective effects of HO-1 in OS-induced apoptosis of human aortic smooth muscle cells (HASMCs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2027-34
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16840713-Apoptosis,
pubmed-meshheading:16840713-Cell Survival,
pubmed-meshheading:16840713-Cytoprotection,
pubmed-meshheading:16840713-Heme Oxygenase-1,
pubmed-meshheading:16840713-Humans,
pubmed-meshheading:16840713-Hydrogen Peroxide,
pubmed-meshheading:16840713-Membrane Potentials,
pubmed-meshheading:16840713-Mitochondria,
pubmed-meshheading:16840713-Muscle, Smooth, Vascular,
pubmed-meshheading:16840713-Myocytes, Smooth Muscle,
pubmed-meshheading:16840713-NF-E2-Related Factor 2,
pubmed-meshheading:16840713-Oxidants,
pubmed-meshheading:16840713-Oxidative Stress,
pubmed-meshheading:16840713-Proteins,
pubmed-meshheading:16840713-Proto-Oncogene Proteins c-akt
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pubmed:year |
2006
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pubmed:articleTitle |
Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT.
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pubmed:affiliation |
Department of Physiology, Queen's University, 18 Stuart St, Kingston, Ontario, K7L 4S7. Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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