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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2006-7-14
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pubmed:abstractText |
The feline homologue of CD134 is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells. However, strains of FIV differ in utilization of CD134; the prototypic strain PPR requires a minimal determinant in the first cysteine-rich domain (CRD1) of feline CD134 to confer near-optimal receptor function, while strains such as GL8 require additional determinants in the CD134 CRD2. We map this determinant to a loop in CRD2 governing the interaction between the receptor and its ligand; the amino acid substitutions S78N-S79Y-K80E restored full viral receptor activity to the CDR2 of human CD134 in the context of feline CD134, with tyrosine-79 appearing to be the critical residue for restoration of receptor function.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-10196258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-10549288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-11164894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-11435556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-11796220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-14976315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-15326292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-15592478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-15661166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-16309726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-16501119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-16537606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-2157591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-8387891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-9024654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16840353-9462508
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7744-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16840353-Amino Acid Substitution,
pubmed-meshheading:16840353-Animals,
pubmed-meshheading:16840353-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16840353-Cats,
pubmed-meshheading:16840353-HeLa Cells,
pubmed-meshheading:16840353-Humans,
pubmed-meshheading:16840353-Immunodeficiency Virus, Feline,
pubmed-meshheading:16840353-Ligands,
pubmed-meshheading:16840353-Protein Structure, Tertiary,
pubmed-meshheading:16840353-Receptors, OX40,
pubmed-meshheading:16840353-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16840353-Receptors, Virus,
pubmed-meshheading:16840353-Tyrosine
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pubmed:year |
2006
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pubmed:articleTitle |
Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus.
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pubmed:affiliation |
Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom. b.willett@vet.gla.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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