Patients with inflammatory bowel disease (IBD) have an increased prevalence of thromboembolic events. The pathogenetic mechanisms of these events include reduced fibrinolysis, which may be caused by antibodies to tissue-type plasminogen activator (t-PA).
Antibodies to tissue-type plasminogen activator (t-PA) in patients with inflammatory bowel disease: high prevalence, interactions with functional domains of t-PA and possible implications in thrombosis.
Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Fondazione Ospedale Policlinico, Mangiagalli and Regina Elena, University of Milan, Via Pace 9, 20122 Milan, Italy.
