| pubmed-article:16837860 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C0024296 | lld:lifeskim |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C0887943 | lld:lifeskim |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16837860 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:16837860 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16837860 | pubmed:dateCreated | 2006-7-27 | lld:pubmed |
| pubmed-article:16837860 | pubmed:abstractText | alpha-Defensins 1, 2, and 3 exert antiretroviral activity in vitro, but their role in controlling HIV-1 replication in vivo and the cells that produce them are controversial. This study sought to determine whether alpha-defensins are present in HIV-1-infected individuals' lymphoid tissues, the major site of HIV-1 replication, and to identify the cells that express them. alpha-Defensin expression was evaluated by immunostaining inguinal lymph node sections from 19 untreated HIV-1-infected individuals and 8 individuals at low risk or seronegative for HIV-1 infection. Percentages of tissue sections that stained positively for alpha-defensins were not significantly different between HIV-seropositive (median, 7.6%) and -seronegative (median, 5.5%) individuals. Conditions that could have produced lymph node inflammation were present in most seronegative subjects, and their lymph node weights correlated with alpha-defensin expression (Spearman rho = 0.833; P = 0.010). A median of 100% (range, 95%-100%) of alpha-defensin-expressing lymph node cells from 8 subjects coexpressed the granulocyte marker, CD15. CD15 and alpha-defensin staining correlated (Spearman rho = 0.622; P < 0.001). These data suggest that alpha-defensins within lymphoid tissue are expressed by granulocytes and are prevalent in HIV-1-seronegative individuals with inflammatory processes as well as HIV-1-infected individuals. The role of alpha-defensins in controlling HIV-1 replication merits further investigation. | lld:pubmed |
| pubmed-article:16837860 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16837860 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16837860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16837860 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16837860 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16837860 | pubmed:issn | 1525-4135 | lld:pubmed |
| pubmed-article:16837860 | pubmed:author | pubmed-author:ConnickElizab... | lld:pubmed |
| pubmed-article:16837860 | pubmed:author | pubmed-author:McCarterMarti... | lld:pubmed |
| pubmed-article:16837860 | pubmed:author | pubmed-author:RyderJohnJ | lld:pubmed |
| pubmed-article:16837860 | pubmed:author | pubmed-author:FolkvordJoy... | lld:pubmed |
| pubmed-article:16837860 | pubmed:author | pubmed-author:ForsterJeri... | lld:pubmed |
| pubmed-article:16837860 | pubmed:author | pubmed-author:MeditzAmie... | lld:pubmed |
| pubmed-article:16837860 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16837860 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16837860 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:16837860 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16837860 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16837860 | pubmed:pagination | 529-36 | lld:pubmed |
| pubmed-article:16837860 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:meshHeading | pubmed-meshheading:16837860... | lld:pubmed |
| pubmed-article:16837860 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16837860 | pubmed:articleTitle | alpha-Defensins 1, 2, and 3 are expressed by granulocytes in lymphoid tissues of HIV-1-seropositive and -seronegative individuals. | lld:pubmed |
| pubmed-article:16837860 | pubmed:affiliation | Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA. | lld:pubmed |
| pubmed-article:16837860 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16837860 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16837860 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16837860 | lld:pubmed |
