Source:http://linkedlifedata.com/resource/pubmed/id/16837860
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2006-7-27
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pubmed:abstractText |
alpha-Defensins 1, 2, and 3 exert antiretroviral activity in vitro, but their role in controlling HIV-1 replication in vivo and the cells that produce them are controversial. This study sought to determine whether alpha-defensins are present in HIV-1-infected individuals' lymphoid tissues, the major site of HIV-1 replication, and to identify the cells that express them. alpha-Defensin expression was evaluated by immunostaining inguinal lymph node sections from 19 untreated HIV-1-infected individuals and 8 individuals at low risk or seronegative for HIV-1 infection. Percentages of tissue sections that stained positively for alpha-defensins were not significantly different between HIV-seropositive (median, 7.6%) and -seronegative (median, 5.5%) individuals. Conditions that could have produced lymph node inflammation were present in most seronegative subjects, and their lymph node weights correlated with alpha-defensin expression (Spearman rho = 0.833; P = 0.010). A median of 100% (range, 95%-100%) of alpha-defensin-expressing lymph node cells from 8 subjects coexpressed the granulocyte marker, CD15. CD15 and alpha-defensin staining correlated (Spearman rho = 0.622; P < 0.001). These data suggest that alpha-defensins within lymphoid tissue are expressed by granulocytes and are prevalent in HIV-1-seronegative individuals with inflammatory processes as well as HIV-1-infected individuals. The role of alpha-defensins in controlling HIV-1 replication merits further investigation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD15,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Defensins,
http://linkedlifedata.com/resource/pubmed/chemical/human neutrophil peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/human neutrophil peptide 2,
http://linkedlifedata.com/resource/pubmed/chemical/human neutrophil peptide 3
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1525-4135
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
529-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16837860-Antigens, CD15,
pubmed-meshheading:16837860-Female,
pubmed-meshheading:16837860-Granulocytes,
pubmed-meshheading:16837860-HIV Infections,
pubmed-meshheading:16837860-Humans,
pubmed-meshheading:16837860-Immunohistochemistry,
pubmed-meshheading:16837860-Inflammation,
pubmed-meshheading:16837860-Lymph Nodes,
pubmed-meshheading:16837860-Lymphoid Tissue,
pubmed-meshheading:16837860-Male,
pubmed-meshheading:16837860-Microscopy, Fluorescence,
pubmed-meshheading:16837860-alpha-Defensins
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pubmed:year |
2006
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pubmed:articleTitle |
alpha-Defensins 1, 2, and 3 are expressed by granulocytes in lymphoid tissues of HIV-1-seropositive and -seronegative individuals.
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pubmed:affiliation |
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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