Source:http://linkedlifedata.com/resource/pubmed/id/16837224
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2006-8-18
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| pubmed:abstractText |
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1096-7192
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| pubmed:author |
pubmed-author:BellGraeme IGI,
pubmed-author:BendlováBelaB,
pubmed-author:BoehnkeMichaelM,
pubmed-author:Bosque-PlataLaura DelLD,
pubmed-author:CoxNancy JNJ,
pubmed-author:DinaChristianC,
pubmed-author:EvansJulie CJC,
pubmed-author:FingerlinTasha ETE,
pubmed-author:FischerSabineS,
pubmed-author:FraylingTimothy MTM,
pubmed-author:FroguelPhilippeP,
pubmed-author:Geoffrey HayesMM,
pubmed-author:GraesslerJuergenJ,
pubmed-author:GroopLeifL,
pubmed-author:HanefeldMarkolfM,
pubmed-author:HanisCraig LCL,
pubmed-author:HansenTorbenT,
pubmed-author:HattersleyAndrew TAT,
pubmed-author:JuliusUlrichU,
pubmed-author:MaleckiMaciej TMT,
pubmed-author:Orho-MelanderMarjuM,
pubmed-author:PalyzováDanielaD,
pubmed-author:PedersenOlufO,
pubmed-author:RietzschHannesH,
pubmed-author:SchulzeJanJ,
pubmed-author:SchwarzPeter E HPE,
pubmed-author:SeliskoThomasT,
pubmed-author:Temelkova-KurktschievTheodoraT,
pubmed-author:TsuchiyaTakafumiT,
pubmed-author:VcelákJosefJ,
pubmed-author:Wayne TowersGG,
pubmed-author:WeedonMichael NMN
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| pubmed:issnType |
Print
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| pubmed:volume |
89
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
174-84
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:16837224-Calpain,
pubmed-meshheading:16837224-Diabetes Mellitus, Type 2,
pubmed-meshheading:16837224-European Continental Ancestry Group,
pubmed-meshheading:16837224-Haplotypes,
pubmed-meshheading:16837224-Humans,
pubmed-meshheading:16837224-Linkage Disequilibrium,
pubmed-meshheading:16837224-Polymorphism, Single Nucleotide
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| pubmed:articleTitle |
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses.
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| pubmed:affiliation |
Departments of Medicine and Human Genetics, The University of Chicago, 5841 S. Maryland Ave., MC1027, Chicago, IL 60637, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Meta-Analysis,
Research Support, N.I.H., Extramural
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