Source:http://linkedlifedata.com/resource/pubmed/id/16836559
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2006-7-13
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| pubmed:abstractText |
Patients undergoing cardiac surgery requiring cardiopulmonary bypass develop a systemic inflammatory reaction. Antithrombin III (AT) has anticoagulant effects but also shows evidence of anti-inflammatory activity. The aim of this study was to examine whether exogenous AT could reduce white blood cell activation (CD11b up regulation or elastase release), in addition to inhibiting platelet (PLT) activation and fibrin generation, during simulated cardiopulmonary bypass (sCPB), undertaken in the absence of endothelium.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0041-1132
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1130-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:16836559-Antigens, CD11b,
pubmed-meshheading:16836559-Antithrombin III,
pubmed-meshheading:16836559-Extracorporeal Circulation,
pubmed-meshheading:16836559-Humans,
pubmed-meshheading:16836559-Inflammation,
pubmed-meshheading:16836559-Models, Biological,
pubmed-meshheading:16836559-Monocytes,
pubmed-meshheading:16836559-Neutrophils,
pubmed-meshheading:16836559-Platelet Aggregation Inhibitors,
pubmed-meshheading:16836559-Up-Regulation
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation.
|
| pubmed:affiliation |
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA. christine.rinder@yale.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|