rdf:type |
|
lifeskim:mentions |
umls-concept:C0003018,
umls-concept:C0010453,
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0041904,
umls-concept:C0086418,
umls-concept:C0086597,
umls-concept:C0145947,
umls-concept:C0162493,
umls-concept:C0185117,
umls-concept:C1710082,
umls-concept:C2911684
|
pubmed:issue |
13
|
pubmed:dateCreated |
2006-7-12
|
pubmed:abstractText |
Angiotensin II (Ang II), a principal effector of renin-angiotensin system (RAS) and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang II receptor type I (AT1) and induce nuclear translocation of signal transducers and activators of transcription (STAT). To further explore the role of Ang II in aging, we examined the effect of Ang II on human replicative senescent diploid fibroblast WI-38 cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0366-6999
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
5
|
pubmed:volume |
119
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1094-102
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16834928-Angiotensin II,
pubmed-meshheading:16834928-Cell Aging,
pubmed-meshheading:16834928-Cells, Cultured,
pubmed-meshheading:16834928-DNA,
pubmed-meshheading:16834928-Fibroblasts,
pubmed-meshheading:16834928-Gene Expression Regulation,
pubmed-meshheading:16834928-Humans,
pubmed-meshheading:16834928-MAP Kinase Signaling System,
pubmed-meshheading:16834928-STAT3 Transcription Factor,
pubmed-meshheading:16834928-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:16834928-Up-Regulation
|
pubmed:year |
2006
|
pubmed:articleTitle |
Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin II-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts.
|
pubmed:affiliation |
Department of Nephrology, General Hospital of People's Liberation Army, Beijing 100853, China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|