|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2006-9-4
|
|
pubmed:abstractText |
Glucocorticoids are used to treat chronic inflammatory diseases such as asthma. Induction of eosinophil apoptosis is considered to be one of the main mechanisms behind the anti-asthmatic effect of glucocorticoids. Glucocorticoid binding to its receptor (GR) can have a dual effect on gene transcription. Activated GR can activate transcription (transactivation), or by interacting with other transcription factors such as NF-kappaB suppress transcription (transrepression). RU24858 has been reported to transrepress but to have little or no transactivation capability in other cell types. The dissociated properties of RU24858 have not been previously studied in non-malignant human cells. As the eosinophils have a very short lifetime and many of the modern molecular biological methods cannot be used, a "dissociated steroid" would be a valuable tool to evaluate the mechanism of action of glucocorticoids in human eosinophils. The aim of this study was to elucidate the ability of RU24858 to activate and repress gene expression in human eosinophils in order to see whether it is a dissociated steroid in human eosinophils.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-10353986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-10411570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-10496964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-10756213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-10856322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-10887309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11012613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11040338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11091183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11112897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11160246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11448148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11694447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11899298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-11970908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-12127907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-12181447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-12496443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-12499651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-12532089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-1438521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-14561153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-15710351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-15753895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-15866175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-16101520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-1940348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-2051022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-2936961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-8466628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-8666816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-8680686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-9103460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-9259316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-9338549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-9449504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16834783-9806739
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:status |
PubMed-not-MEDLINE
|
|
pubmed:issn |
1476-9255
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
10
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils.
|
|
pubmed:affiliation |
The Immunopharmacology Research Group, Medical School, FIN-33014 University of Tampere and Research Unit, Tampere University Hospital, Tampere, Finland. mirkka.janka@uta.fi
|
|
pubmed:publicationType |
Journal Article
|
