Source:http://linkedlifedata.com/resource/pubmed/id/16832152
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0006560,
umls-concept:C0017337,
umls-concept:C0229671,
umls-concept:C0392683,
umls-concept:C0439830,
umls-concept:C0439849,
umls-concept:C0441889,
umls-concept:C0445223,
umls-concept:C0678544,
umls-concept:C1552599,
umls-concept:C1556094,
umls-concept:C1704787,
umls-concept:C1882417
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| pubmed:issue |
5
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| pubmed:dateCreated |
2006-7-11
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| pubmed:abstractText |
The objective of this study was to clarify relationships between the C-reactive protein (CRP) gene and both the serum level of CRP and arterial pulse wave velocity (PWV), using haplotype analysis of healthy elderly Japanese. Five single-nucleotide polymorphisms (SNPs) of the human CRP gene (rs1341665, rs3091244, rs1800947, rs1130864 and rs1205) were used to genotype 315 healthy elderly Japanese subjects (mean age, 77.9 +/- 4.1 years; male/female ratio, 0.96). Linkage disequilibrium was analyzed for the five SNPs. The frequency of each haplotype and diplotype was estimated using the expectation/maximization (EM) algorithm. There were statistically significant associations between the CRP level and two CRP genotypes; the p value for the T allele of rs3091244 (CT + AT + TT vs. CC + CA + AA) was 0.002 (95% confidential interval [CI], 2.1-24), and the p value for the T allele of rs1130864 (TT + TC vs. CC) was 0.002 (95% CI, 2.1-24). The only genotype that was significantly associated with arterial PWV was the C allele of rs1800947, with a p value of 0.039. The haplotype was constructed using rs1341665, rs3091244 and rs1800947, in that order. There was a significant association between the CRP level and the T-T-G haplotype, with a p value of 0.002 (95% CI, 2.1-24). There was a significant association between arterial PWV and the C-C-C haplotype, with a p value of 0.039. We concluded that rs3091244, rs1130864 and the T-T-G haplotype are genetic markers for elevated basal CRP levels. rs1800947 and the C-C-C haplotype appear to be susceptibility markers for atherosclerosis, but this requires confirmation.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0916-9636
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
323-31
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16832152-Age Factors,
pubmed-meshheading:16832152-Aged,
pubmed-meshheading:16832152-Aged, 80 and over,
pubmed-meshheading:16832152-Algorithms,
pubmed-meshheading:16832152-Alleles,
pubmed-meshheading:16832152-Arteriosclerosis,
pubmed-meshheading:16832152-Blood Pressure,
pubmed-meshheading:16832152-C-Reactive Protein,
pubmed-meshheading:16832152-Female,
pubmed-meshheading:16832152-Genetic Markers,
pubmed-meshheading:16832152-Genetic Predisposition to Disease,
pubmed-meshheading:16832152-Genotype,
pubmed-meshheading:16832152-Haplotypes,
pubmed-meshheading:16832152-Humans,
pubmed-meshheading:16832152-Hypertension,
pubmed-meshheading:16832152-Japan,
pubmed-meshheading:16832152-Linkage Disequilibrium,
pubmed-meshheading:16832152-Male,
pubmed-meshheading:16832152-Polymorphism, Single Nucleotide
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| pubmed:year |
2006
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| pubmed:articleTitle |
Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.
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| pubmed:affiliation |
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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