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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
36
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pubmed:dateCreated |
2006-9-4
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pubmed:abstractText |
Our previous studies have revealed that the signaling protein BCL10 plays a major role in adaptive immunity by mediating NF-kappaB activation in the LPS/TLR4 pathway. In this study, we show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4 signaling complex and mediates signaling to NF-kappaB through the BCL10-MALT1-TRAF6-TAK1 cascade. Following dissociation from IRAK-1, BCL10 is translocated into the cytosol along with TRAF6 and TAK1, in a process bridged by a direct BCL10-Pellino2 interaction. RNA interference against MALT1 markedly reduced the level of NF-kappaB activation stimulated by lipopolysaccharide (LPS) in macrophages, which suggests that MALT1 plays a major role in the LPS/TLR4 pathway. MALT1 interacted with BCL10 and TRAF6 to facilitate TRAF6 self-ubiquitination in the cytosol, which was strictly dependent on the dissociation of BCL10 from IRAK-1. We show that BCL10 oligomerization is a prerequisite for BCL10 function in LPS signaling to NF-kappaB and that IRAK-1 dimerization is an important event in this process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/BCL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP kinase kinase kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Malt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peli2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26029-40
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16831874-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16831874-Amino Acid Sequence,
pubmed-meshheading:16831874-Animals,
pubmed-meshheading:16831874-Caspases,
pubmed-meshheading:16831874-Cell Line,
pubmed-meshheading:16831874-Dimerization,
pubmed-meshheading:16831874-Humans,
pubmed-meshheading:16831874-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:16831874-Lipopolysaccharides,
pubmed-meshheading:16831874-MAP Kinase Kinase Kinases,
pubmed-meshheading:16831874-Macrophages,
pubmed-meshheading:16831874-Mice,
pubmed-meshheading:16831874-Molecular Sequence Data,
pubmed-meshheading:16831874-NF-kappa B,
pubmed-meshheading:16831874-Neoplasm Proteins,
pubmed-meshheading:16831874-Nuclear Proteins,
pubmed-meshheading:16831874-Protein Structure, Quaternary,
pubmed-meshheading:16831874-RNA Interference,
pubmed-meshheading:16831874-Signal Transduction,
pubmed-meshheading:16831874-TNF Receptor-Associated Factor 6,
pubmed-meshheading:16831874-Toll-Like Receptor 4
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pubmed:year |
2006
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pubmed:articleTitle |
The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.
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pubmed:affiliation |
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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