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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-11
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pubmed:abstractText |
A recent study has suggested that the methylation silencing of the suppressor of cytokine signaling-3 (SOCS3), a negative regulator of interleukin-6-related cytokines, could be involved in hepatocellular carcinoma (HCC). However, the roles of SOCS3 in hepatocellular carcinogenesis and hepatitis have not been established. We investigated the effect of deleting the SOCS3 gene on the development of hepatitis and HCC in hepatitis C virus-infected patients and mouse models.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:ChinenTakatoshiT,
pubmed-author:IidaMitsuoM,
pubmed-author:KobayashiTakashiT,
pubmed-author:KogaKeikoK,
pubmed-author:MaeharaYoshihikoY,
pubmed-author:MinodaYasumasaY,
pubmed-author:OgataHisanobuH,
pubmed-author:SanadaTakahitoT,
pubmed-author:TakaesuGiichiG,
pubmed-author:TakakiHiromiH,
pubmed-author:YoshimuraAkihikoA
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-93
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16831601-Adult,
pubmed-meshheading:16831601-Aged,
pubmed-meshheading:16831601-Animals,
pubmed-meshheading:16831601-Carcinoma, Hepatocellular,
pubmed-meshheading:16831601-Concanavalin A,
pubmed-meshheading:16831601-Drug-Induced Liver Injury,
pubmed-meshheading:16831601-Female,
pubmed-meshheading:16831601-Gene Deletion,
pubmed-meshheading:16831601-Hepatocytes,
pubmed-meshheading:16831601-Humans,
pubmed-meshheading:16831601-Immunohistochemistry,
pubmed-meshheading:16831601-Liver Neoplasms,
pubmed-meshheading:16831601-Male,
pubmed-meshheading:16831601-Mice,
pubmed-meshheading:16831601-Middle Aged,
pubmed-meshheading:16831601-RNA, Neoplasm,
pubmed-meshheading:16831601-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16831601-Suppressor of Cytokine Signaling Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
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pubmed:affiliation |
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Science, Kyushu University, Higashiku, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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