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| pubmed-article:16830071 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:16830071 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:16830071 | lifeskim:mentions | umls-concept:C1513371 | lld:lifeskim |
| pubmed-article:16830071 | lifeskim:mentions | umls-concept:C1971814 | lld:lifeskim |
| pubmed-article:16830071 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16830071 | pubmed:dateCreated | 2006-10-23 | lld:pubmed |
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| pubmed-article:16830071 | pubmed:abstractText | Several families of endogenous retrovirus (ERV) exist in copious numbers in the genomes of primate species. Therefore, we undertook a systematic search for endogenous retrovirus sequences from the ERV-K family, comparing across both human (Homo sapiens) and chimpanzee (Pan troglodytes) genomes. Using conserved motifs of the ERV-K as query we identified and characterized 76 complete ERV-K elements, 54 in human (HERV-K), 34 of which were described previously, and 21 in the chimpanzee (CERV-K). Phylogenetic analysis using coding regions and LTRs showed the existence of two main branches. Group I was the most heterogeneous and had an average integration time of 18.3 MYBP (million years before present), using rates ranging from 1.5 to 4.0 x 10(-9) s/s/y (substitution per site per year). Group O/N integrated around 19.4 MYBP and nested Group N integrated about 14 MYBP. We found evidence for strong positive selection on the gag, pol and env coding regions and for A/T hypermutation. Our data suggest that the endogenous elements were possibly involved in chromosomal rearrangements and retained a great deal of information from their active stage, most likely as a consequence of host interactions. This study also contributes to the annotation effort of both human and chimpanzee genomes. | lld:pubmed |
| pubmed-article:16830071 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16830071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16830071 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16830071 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16830071 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16830071 | pubmed:issn | 0304-8608 | lld:pubmed |
| pubmed-article:16830071 | pubmed:author | pubmed-author:RomanoC MCM | lld:pubmed |
| pubmed-article:16830071 | pubmed:author | pubmed-author:RamalhoR FRF | lld:pubmed |
| pubmed-article:16830071 | pubmed:author | pubmed-author:ZanottoP M... | lld:pubmed |
| pubmed-article:16830071 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16830071 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:16830071 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16830071 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16830071 | pubmed:pagination | 2215-28 | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
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| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:meshHeading | pubmed-meshheading:16830071... | lld:pubmed |
| pubmed-article:16830071 | pubmed:year | 2006 | lld:pubmed |
