Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2006-10-23
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112093, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112094, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112095, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112096, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112097, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112098, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112099, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112100, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112101, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112102, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112103, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112104, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112105, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112106, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112107, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112108, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112109, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112110, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112111, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112112, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112113, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112114, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112115, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112116, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112117, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112118, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112119, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112120, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112121, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112122, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112123, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112124, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112125, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112126, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112127, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112128, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112129, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112130, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112131, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112132, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112133, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112134, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112135, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112136, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112137, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112138, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112139, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112140, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112141, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112142, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112143, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112144, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112145, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112146, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112147, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112148, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112149, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112150, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112151, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112152, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112153, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112154, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112155, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ112156
pubmed:abstractText
Several families of endogenous retrovirus (ERV) exist in copious numbers in the genomes of primate species. Therefore, we undertook a systematic search for endogenous retrovirus sequences from the ERV-K family, comparing across both human (Homo sapiens) and chimpanzee (Pan troglodytes) genomes. Using conserved motifs of the ERV-K as query we identified and characterized 76 complete ERV-K elements, 54 in human (HERV-K), 34 of which were described previously, and 21 in the chimpanzee (CERV-K). Phylogenetic analysis using coding regions and LTRs showed the existence of two main branches. Group I was the most heterogeneous and had an average integration time of 18.3 MYBP (million years before present), using rates ranging from 1.5 to 4.0 x 10(-9) s/s/y (substitution per site per year). Group O/N integrated around 19.4 MYBP and nested Group N integrated about 14 MYBP. We found evidence for strong positive selection on the gag, pol and env coding regions and for A/T hypermutation. Our data suggest that the endogenous elements were possibly involved in chromosomal rearrangements and retained a great deal of information from their active stage, most likely as a consequence of host interactions. This study also contributes to the annotation effort of both human and chimpanzee genomes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-8608
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2215-28
pubmed:meshHeading
pubmed:year
2006
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