16829048

Source:http://linkedlifedata.com/resource/pubmed/id/16829048

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0036341, umls-concept:C0036363, umls-concept:C0042789, umls-concept:C1306673
pubmed:issue	1-3
pubmed:dateCreated	2006-8-22
pubmed:abstractText	Previous studies of visual perception have reported deficits in contrast sensitivity and dot motion discrimination in schizophrenia. We tested whether these deficits also appear in schizotypal personality disorder (SPD). SPD appears to be genetically and symptomatically related to schizophrenia, but without the marked psychosocial impairment associated with psychotic disorders. The present study investigated contrast sensitivity for moving and static gratings, form discrimination and dot motion discrimination in 24 patients with schizophrenia or schizoaffective disorder (SZ), 16 individuals with SPD, and 40 control subjects. SZ, but not SPD subjects, showed impairments on tests of contrast sensitivity for static and moving gratings, form discrimination in noise, and dot motion discrimination. Visual performance did not differ between medicated SZ patients and patients withdrawn from medication. These results confirm early stage visual deficits in schizophrenia regardless of medication status. SPD subjects, in contrast, show intact early stage visual processing despite the presence of marked schizotypal symptoms.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/1 R01 MH62150-01
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8804207
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0920-9964
pubmed:author	pubmed-author:BismarkAndrewA, pubmed-author:BodkinsMistyM, pubmed-author:HetrickWilliam PWP, pubmed-author:O'DonnellBrian FBF, pubmed-author:ShekharAnanthaA, pubmed-author:VohsJenifer LJL
pubmed:issnType	Print
pubmed:volume	86
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	89-98
pubmed:dateRevised	2010-9-2
pubmed:meshHeading	pubmed-meshheading:16829048-Adult, pubmed-meshheading:16829048-Analysis of Variance, pubmed-meshheading:16829048-Antipsychotic Agents, pubmed-meshheading:16829048-Contrast Sensitivity, pubmed-meshheading:16829048-Discrimination (Psychology), pubmed-meshheading:16829048-Female, pubmed-meshheading:16829048-Humans, pubmed-meshheading:16829048-Male, pubmed-meshheading:16829048-Middle Aged, pubmed-meshheading:16829048-Neuropsychological Tests, pubmed-meshheading:16829048-Photic Stimulation, pubmed-meshheading:16829048-Psychiatric Status Rating Scales, pubmed-meshheading:16829048-Reaction Time, pubmed-meshheading:16829048-Schizophrenia, pubmed-meshheading:16829048-Schizotypal Personality Disorder, pubmed-meshheading:16829048-Sensory Thresholds, pubmed-meshheading:16829048-Statistics as Topic, pubmed-meshheading:16829048-Vision, Ocular, pubmed-meshheading:16829048-Visual Perception
pubmed:year	2006
pubmed:articleTitle	Early stage vision in schizophrenia and schizotypal personality disorder.
pubmed:affiliation	Department of Psychology, Indiana University, Bloomington, IN, USA. bodonnel@indiana.edu
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Evaluation Studies, Research Support, N.I.H., Extramural