Linked Life Data

1682786

Source:http://linkedlifedata.com/resource/pubmed/id/1682786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-12-23
pubmed:abstractText
Much has been learned about the function of glutathione (GSH) and other thiols as antioxidants, radioprotectors and radical scavengers. Recent reports point out that GSH and other thiols are double-edged swords: they induce the formation of free radicals and oxidative damage. Such damage is responsible for most, if not all, genotoxicity of GSH to bacteria, and probably to mammalian cells as well. The activation of GSH to an oxidative mutagen and induction of oxidative damage by GSH are catalysed by gamma-glutamyl transpeptidase (GGT), an enzyme appearing very frequently in enzyme-altered foci in livers of rodents, shortly after their exposure to carcinogens. It is proposed here that such GGT-dependent oxidative damage may help in the promotion stage in tumourigenesis, and in that its function may be similar to that of peroxisome proliferators as promotors of hepatocarcinogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0267-8357
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Oxidative metabolism of glutathione by gamma-glutamyl transpeptidase and peroxisome proliferation: the relevance to hepatocarcinogenesis. A hypothesis.
pubmed:affiliation
Department of Biochemistry, Tel-Aviv University, Ramat-Aviv, Israel.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't