16827817

Source:http://linkedlifedata.com/resource/pubmed/id/16827817

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014792, umls-concept:C0017205, umls-concept:C0030705, umls-concept:C0332621
pubmed:issue	4
pubmed:dateCreated	2006-8-2
pubmed:abstractText	Gaucher disease is associated with increased red blood cell (RBC) aggregation, but the pathophysiological significance of this phenomenon and its correlation with disease manifestations are unclear. RBC aggregation was evaluated in 43 patients with Gaucher disease and 53 healthy controls. Dynamic RBC aggregation was examined in a narrow-gap flow chamber at varying shear stress. Compared with the controls, RBC aggregation in Gaucher disease was increased by 25%. Comparison of RBC aggregation in autologous plasma and in dextran (500 kDa) showed an increase both in plasma-dependent (extrinsic) and -independent (intrinsic) RBC aggregation. Subgroup analysis revealed that increased RBC aggregation was limited to patients with an intact spleen. RBC aggregation in patients did not correlate with plasma fibrinogen concentration, disease severity, enzyme replacement therapy or genotype. We conclude that RBC aggregation is increased in patients with Gaucher disease and an intact spleen, possibly reflecting the accumulation of glucocerebroside and other substances in the plasma and RBC membranes of these patients. Our results do not support a role for RBC aggregation in the pathogenesis of vascular complications of Gaucher disease.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372544
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein, http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0007-1048
pubmed:author	pubmed-author:AdarTomerT, pubmed-author:BarshteinGershonG, pubmed-author:Ben-AmiRonenR, pubmed-author:BerlinerShlomoS, pubmed-author:ElsteinDeborahD, pubmed-author:YedgarSaulS, pubmed-author:ZimranAriA
pubmed:issnType	Print
pubmed:volume	134
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	432-7
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16827817-Adult, pubmed-meshheading:16827817-Analysis of Variance, pubmed-meshheading:16827817-Blood Sedimentation, pubmed-meshheading:16827817-C-Reactive Protein, pubmed-meshheading:16827817-Case-Control Studies, pubmed-meshheading:16827817-Erythrocyte Aggregation, pubmed-meshheading:16827817-Erythrocyte Deformability, pubmed-meshheading:16827817-Female, pubmed-meshheading:16827817-Fibrinogen, pubmed-meshheading:16827817-Flow Cytometry, pubmed-meshheading:16827817-Gaucher Disease, pubmed-meshheading:16827817-Humans, pubmed-meshheading:16827817-Male, pubmed-meshheading:16827817-Middle Aged, pubmed-meshheading:16827817-Splenectomy
pubmed:year	2006
pubmed:articleTitle	Aggregation of red blood cells in patients with Gaucher disease.
pubmed:affiliation	Gaucher Clinic, Shaare Zedek Medical Centre, Jerusalem, Israel.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't