Linked Life Data

16827159

Source:http://linkedlifedata.com/resource/pubmed/id/16827159

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3A
pubmed:dateCreated
2006-7-7
pubmed:abstractText
The wild sarsaparilla (Aralia nudicaulis) plant is richly distributed in North America, mainly in Canada. In the present study, 24 extracts were obtained from the rhizome, stem, leaf and fruit of wild sarsaparilla. In the presence of RH (hexane fraction from the rhizome), the survival rate of WiDr (human colon cancer cell) was 3.5 +/- 2.7% (IC50 = 30.1 +/- 3.5 microg/ml) and that of Molt (human leukemia cell) was 2.4 +/- 2.8% (IC50 = 7.0 +/- 0.6 microg/ml). The survival rate of HELA (human cervix cancer cell) was only 1.8 +/- 0.9% in the presence of FH (hexane fraction from the fruit of wild sarsaparilla) (IC50 = 33.3 +/- 2.7 microg/ml). The cytotoxicities of RH and FH against normal human umbilical vein endothelial cells were significantly lower than against the tested human cancer cells. RH appeared to be the best extract against WiDr and Molt, whereas FH was the most effective against HELA. Because of the rich natural supply, simple extraction procedure and high yield, RH and FH of wild sarsaparilla have the potential to be developed into selective anticancer nutraceutical and/or pharmaceutical products with few side-effects and low cost.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2157-64
pubmed:meshHeading
pubmed:articleTitle
Anticancer effect of extracts from a North American medicinal plant--wild sarsaparilla.
pubmed:affiliation
Walter Murray Collegiate, 1905 Preston Ave., Saskatoon, Saskatchewan, Canada.
pubmed:publicationType
Journal Article