| pubmed-article:16826163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C1414928 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16826163 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16826163 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16826163 | pubmed:dateCreated | 2006-8-17 | lld:pubmed |
| pubmed-article:16826163 | pubmed:abstractText | Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreactive T cells, which are involved in autoimmune diseases. However, it is unknown whether attenuated activated healthy autologous T-cell immunization could increase anti-tumor immune responses. To this end, C57Bl/6 mice were immunized with attenuated activated autologous T cells. The splenocytes from immunized mice showed a higher proliferative ability than that from naive mice. The special phenotype analysis showed that there were more CD8+ T cells and CD62L+ T cells in immunized mice after 24 h of culture with 10% fetal calf serum complete medium in vitro (P<0.01). These results demonstrated that this immunization may activate T cells in vivo. Furthermore, the splenocytes from immunized mice revealed resistance to activation-induced cell death (AICD) in vitro. To further study the relative genes that are responsible for the higher proliferation and resistance to AICD, the expression of Fas/Fas ligand (FasL) and GADD45b was measured by real-time PCR. The results indicated that GADD45beta transcription was higher in the splenocytes from immunized mice than that in the naive mice. In addition, the Fas expression showed a parallel higher, but FasL did not change obviously. To investigate the biologic functions induced by immunization in vivo, a tumor model was established by EL-4 tumor cell inoculation in C57/Bl mice. Mice receiving autologous T-cell immunization had significantly inhibited tumor growth in vivo (P<0.01). This study implicated that immunization with attenuated activated autologous T cells enhances anti-tumor immune responses that participate in tumor growth inhibition. | lld:pubmed |
| pubmed-article:16826163 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16826163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16826163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16826163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16826163 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16826163 | pubmed:issn | 1748-7838 | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:DulRR | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:ZhangYanY | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:WangLiL | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:ZhangJingwuJ | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:LiNingliN | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:ShenBaihuaB | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:DuFangF | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:ShengHuimingH | lld:pubmed |
| pubmed-article:16826163 | pubmed:author | pubmed-author:DiaoYingnaY | lld:pubmed |
| pubmed-article:16826163 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16826163 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16826163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16826163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16826163 | pubmed:pagination | 702-12 | lld:pubmed |
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| pubmed-article:16826163 | pubmed:meshHeading | pubmed-meshheading:16826163... | lld:pubmed |
| pubmed-article:16826163 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16826163 | pubmed:articleTitle | Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45beta. | lld:pubmed |
| pubmed-article:16826163 | pubmed:affiliation | Shanghai Jiao Tong University School of Medicine, Shanghai, China. | lld:pubmed |
| pubmed-article:16826163 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16826163 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17873 | entrezgene:pubmed | pubmed-article:16826163 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16826163 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16826163 | lld:pubmed |
