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pubmed-article:1682595pubmed:abstractTextAlthough lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection by Helicobacter pylori, and we have confirmed this in 450 patients with H pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases of gastric MALT lymphoma and found H pylori infection in 101 of these (92%). We conclude that gastric MALT is acquired in H pylori infection and that this provides the necessary background in which MALT lymphoma might develop.lld:pubmed
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pubmed-article:1682595pubmed:articleTitleHelicobacter pylori-associated gastritis and primary B-cell gastric lymphoma.lld:pubmed
pubmed-article:1682595pubmed:affiliationDepartment of Histopathology, University College and Middlesex School of Medicine, London, UK.lld:pubmed
pubmed-article:1682595pubmed:publicationTypeJournal Articlelld:pubmed
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