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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-12-4
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pubmed:databankReference |
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pubmed:abstractText |
Genomic imprinting refers to an epigenetic marking resulting in monoallelic gene expression and has a critical role in fetal development. Various imprinting diseases have recently been reported in humans and animals born after the use of assisted reproductive technology (ART). All the epimutations implicated involve a loss of methylation of the maternal allele (demethylation of KvDMR1/KCNQ1OT1 in Beckwith-Wiedemann syndrome (BWS), demethylation of SNRPN in Angelman syndrome and demethylation of DMR2/IGF2R in large offspring syndrome), suggesting that ART impairs the acquisition or maintenance of methylation marks on maternal imprinted genes. However, it is unknown whether this epigenetic imprinting error is random or restricted to a specific imprinted domain.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-10958657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-11175780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-11253064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-11267669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-11433041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-11436121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-12016591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-12019213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-12439823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-12525545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-12549484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-12772698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-14500540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-14511489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-14998934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15240554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15284956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15314640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15372379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15580563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15705373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15743916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15805153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-15888726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-16403808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-8267611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-8595419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-8755558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16825435-9771709
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/KCNQ1OT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins, Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/SNRPN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/mesoderm specific transcript protein,
http://linkedlifedata.com/resource/pubmed/chemical/snRNP Core Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1468-6244
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
902-7
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pubmed:dateRevised |
2010-9-15
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pubmed:meshHeading |
pubmed-meshheading:16825435-Autoantigens,
pubmed-meshheading:16825435-Beckwith-Wiedemann Syndrome,
pubmed-meshheading:16825435-Blotting, Southern,
pubmed-meshheading:16825435-Chromosomes, Human, Pair 11,
pubmed-meshheading:16825435-CpG Islands,
pubmed-meshheading:16825435-DNA,
pubmed-meshheading:16825435-DNA Methylation,
pubmed-meshheading:16825435-Female,
pubmed-meshheading:16825435-Genomic Imprinting,
pubmed-meshheading:16825435-Humans,
pubmed-meshheading:16825435-Male,
pubmed-meshheading:16825435-Membrane Proteins,
pubmed-meshheading:16825435-Potassium Channels, Voltage-Gated,
pubmed-meshheading:16825435-Proteins,
pubmed-meshheading:16825435-Receptor, IGF Type 2,
pubmed-meshheading:16825435-Reproductive Techniques, Assisted,
pubmed-meshheading:16825435-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:16825435-snRNP Core Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
The epigenetic imprinting defect of patients with Beckwith-Wiedemann syndrome born after assisted reproductive technology is not restricted to the 11p15 region.
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pubmed:affiliation |
Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.
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pubmed:publicationType |
Journal Article
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