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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-7-7
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pubmed:abstractText |
The purpose of this study was to use objective quantitative magnetic resonance imaging (MRI) methods to develop a computer-aided detection (CAD) tool to differentiate white matter (WM) hyperintensities into either leukoencephalopathy (LE) induced by chemotherapy or normal maturational processes in children treated for acute lymphoblastic leukemia without irradiation. A combined MRI set consisting of T1-weighted, T2-weighted, proton-density-weighted and fluid-attenuated inversion recovery images and WM, gray matter and cerebrospinal fluid proportional volume maps from a spatially normalized atlas were analyzed with a neural network segmentation based on a Kohonen self-organizing map (SOM). Segmented maps were manually classified to identify the most hyperintense WM region and the normal-appearing genu region. Signal intensity differences normalized to the genu within each examination were generated for four time points in 228 children. A second Kohonen SOM was trained on the first examination data and divided the WM into normal-appearing or LE groups. Reviewing labels from the CAD tool revealed a consistency measure of 89.8% (167 of 186) within patients. The overall agreement between the CAD tool and the consensus reading of two trained observers was 84.1% (535 of 636), with 84.2% (170 of 202) agreement in the training set and 84.1% (365 of 434) agreement in the testing set. These results suggest that subtle therapy-induced LE can be objectively and reproducibly detected in children treated for cancer using this CAD approach based on relative differences in quantitative signal intensity measures normalized within each examination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-10408769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-10871022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-11070477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-11562622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-14517694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-14523961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-14576448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-15062925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-1525778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-15562471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-18267756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-2052695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-8498647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-9045302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-9468466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16824973-9586883
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0730-725X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
785-91
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16824973-Adolescent,
pubmed-meshheading:16824973-Algorithms,
pubmed-meshheading:16824973-Antimetabolites, Antineoplastic,
pubmed-meshheading:16824973-Brain Diseases,
pubmed-meshheading:16824973-Child,
pubmed-meshheading:16824973-Child, Preschool,
pubmed-meshheading:16824973-Diagnosis, Computer-Assisted,
pubmed-meshheading:16824973-Diagnosis, Differential,
pubmed-meshheading:16824973-Female,
pubmed-meshheading:16824973-Humans,
pubmed-meshheading:16824973-Image Processing, Computer-Assisted,
pubmed-meshheading:16824973-Infant,
pubmed-meshheading:16824973-Magnetic Resonance Imaging,
pubmed-meshheading:16824973-Male,
pubmed-meshheading:16824973-Methotrexate,
pubmed-meshheading:16824973-Precursor Cell Lymphoblastic Leukemia-Lymphoma
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pubmed:year |
2006
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pubmed:articleTitle |
Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate.
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pubmed:affiliation |
Division of Translational Imaging Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. john.glass@stjude.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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