Linked Life Data

16824758

Source:http://linkedlifedata.com/resource/pubmed/id/16824758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2006-8-14
pubmed:abstractText
A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with beta-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4893-7
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Synthesis and cardiac effects of 3,4-dihydropyrimidin-2(1H)-one-5 carboxylates.
pubmed:affiliation
Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (DU), Porur, Chennai 600 116, India.
pubmed:publicationType
Journal Article